Use of Localization and Activity of Thymidine Phosphorylase in Human Gynecological Tumors for Predicting Sensitivity to Pyrimidine Antimetabolite Therapy: An Observational Study
نویسندگان
چکیده
1Department of Obstetrics and Gynecology, Jikei University School of Medicine, Japan 2Department of Obstetrics and Gynecology, Tokyo Medical School, Japan 3S.S Ladies Clinic, Japan 4Department of Obstetrics and Gynecology, Faculty of Medicine, Tohoku University, Japan 5Department of Obstetrics and Gynecology, Inamino Hospital, Japan 6Department of Obstetrics and Gynecology, Kurume University, Faculty of Medicine, presently department of Obstetrics and Gynecology, Chikugo City Hospital, Japan 7Department of Pathology, Nippon Medical School Hospital, Japan 8Department of Obstetrics and Gynecology, Kinki University Hospital, Japan 9Department of Obstetrics and Gynecology, Saiseikai Shigaken Hospital, Japan
منابع مشابه
تعیین فعالیت آنزیم تیمیدین فسفریلاز گلبولهای سفید و تیمیدین پلاسما در بیماران MNGIE بهروش کروماتوگرافی مایع با کارایی بالا- فاز معکوس (RP-HPLC)
Background: Thymidine phosphorylase (TP) catalyses the conversion of thymidine into thymine. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disease which is caused by mutations in the nuclear gene encoding TP, bringing about severe impairment of TP-enzyme specific activity and accumulation of thymidine in plasma. The clinical manifestations of MNGIE are ...
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Two distinct pyrimidine nucleosidases, isolated from Escheri&a coli, show complete specificity for the pentose moiety of the nucleoside. Pyrimidine deoxyribonucleoside phosphorylase (1) shows complete specificity for the deoxyribosyl group, and uridine phosphorylase (2) for the ribosyl group. Mammalian uridine phosphorylase preparations (3, 4), however, have appreciable deoxyuridine phosphoryla...
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Human thymidine phosphorylase (HTP), also known as platelet-derived endothelial cell growth factor (PD-ECGF), is overexpressed in certain solid tumors where it is linked to poor prognosis. HTP expression is utilized for certain chemotherapeutic strategies and is also thought to play a role in tumor angiogenesis. We determined the structure of HTP bound to the small molecule inhibitor 5-chloro-6...
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Nucleoside : purine (pyrimidine) deoxyribosyltransferase activity (EC 2.4.2.6.) has been demonstrated in bacteria by a number of investigators (l-5). Similar activity in mammalian tissues was reported by deVerdier and Potter (6). With the mammalian enzyme, however, the substrate specificity of the transfer reaction appeared to be restricted to pyrimidine bases and their deoxyribonucleosides. Tr...
متن کاملThe activity of thymidine phosphorylase obtained from human uterine leiomyomas and studied in the presence of pyrimidine derivatives.
Partially purified samples of thymidine phosphorylase were obtained from four preparations of human uterine leiomyomas and uteri using the method of Yoshimura et al. (1990), Biochim. Biophys. Acta 1034, 107-113. Among the studied twelve pyrimidine derivatives, 5-bromouracil, 5-nitrouracil, 5-fluorouracil, 6-aminouracil, 4, 6-dihydroxy-5-nitropyrimidine are competitive inhibitors, while allyloxy...
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